Aptagen, LLC
DNA
Neuropeptide Y (NPY)
Peptide
300 nM (reported value)
Capillary Electrophoresis Separation Buffer: 20 mM Hepes (pH 7.3) with 10 mM NaCl
RT°C
NA If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.
The specificity for neuropeptide Y over the similar human pancreatic polypeptide (hPP; ~50% sequence homology)was 42-fold.
Neuropeptide Y (Clone 4.31) (ID# 440)
5'dApdGpdCpdApdGpdCpdApdCpdApdGpdApdGpdGpdTpdCpdApdGpdApdTpdGpdCpdApdApdApdCpdCpdApdCpdApdGpdCpdCpdTpdGpdApdGpdTpdGpdGpdTpdTpdApdGpdCpdGpdTpdApdTpdGpdTpdCpdApdTpdTpdTpdApdCpdGpdGpdApdCpdCpdTpdApdTpdGpdCpdGpdTpdGpdCpdTpdApdCpdCpdGpdTpdGpdApdAp3'
80
24737.1 g/mole
783500 L/(mole·cm)
51.25%
1.28
31.57
Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.
S.D. Mendonsa and M.T. Bowser. In vitro selection of aptamers with affinity for neuropeptide Y using capillary electrophoresis. J. Am. Chem. Soc. 127(2005): 9382-9383.
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